|
KMID : 0942820060050010023
|
|
Journal of Korean Brain Tumor Society
2006 Volume.5 No. 1 p.23 ~ p.28
|
|
|
The Relationship of TGF-β1 and Smad4 Expression to the Histologic Grade of Astroma
|
|
Kim Byung-Joo
Song Geun-Seong
Seo Young-Jun
|
|
|
Abstract
|
|
|
Smads are signal transducers for the members of TGF-beta superfamily. Understanding the function of Smads in tumor cells is of paramount importance, since most tumors with defects in TGF-beta signaling still have functional components of Smads pathways that may play critical roles in determining the malignant phenotypes. Of these Smads, Smad4 is essential for TGF-beta signaling. The purpose of this study was to elucidate TGF-beta 1 and Smad4 protein expression in human astrocytomas and its pathological significance by using immunohistochemical technique. A total 54 astrocytomas among the patients who underwent operation at Pusan National University Hospital between Jan., 1996 and Dec., 2001 were included in the study. Histologically the tumors were graded as three groups according to the WHO grading system and 15 cases were in grade II(low grade astrocytoma), 19 cases in grade III(anaplastic astrocytoma) and 20 cases in grade IV(glioblastoma multiforme). As a result, TGF-β1 expression tended to increase with increasing grade of malignancy. Expression of Smad4 was higher in grade II astrocytoma than grade IV astrocytoma. The univariate analysis showed that there was significant difference between the malignancy and expression of TGF-β1 and Smad4(p<0.05).
In conclusion, it is presented that reduced Smad4 expression and high TGF-β1 expression might be significantly associated with increased malignancy and invasiveness of astrocytoma.
|
|
|
KEYWORD
|
|
|
TGF-β1, Smad4, Astrocytoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|